Eugenic superhumans, self-aware computers, and superior space aliens are extremely unlikely to enslave or exterminate mankind. This is so, no matter how much we well deserve it! Many of those science fiction novels and films taking up this catastrophic thesis are wonderfully melodramatic and a ton of fun. But they simply aren't very realistic.
Almost certainly these future, ultra-formidable life forms will gaze upon us as we humans today look at ant colonies and insect culture. Almost invariably we human beings don't want to enslave or exterminate our humble insect friends because these two highly aggressive behaviors offer us no real value, profit, benefit, or pleasure. Moreover, we homo sapiens very much tend to see the wanton destruction of these defenseless, and relatively harmless and peaceable, creatures as inhuman and immoral. Absent some overwhelmingly strong and strange reason, we humans view such a senseless and irrational attack upon such modest, but still sacred, life as a violation of our moral code. Human beings simply don't assault such innocent and irrelevant life forms.
So when modern human people eventually encounter and confront eugenic superhumans, self-aware computers, or superior space aliens -- or even all three at once! -- these superbeings are immensely unlikely to attack us either. Enslavement or extermination simply isn't in the offing. Especially not if we live our lives as, and turn ourselves into, upstanding, worthy, noble creatures who love life, work hard, don't initiate force against our fellows, and are generally decent, civilized, and high-minded. Our technologically-, intellectually-, and morally-superior new friends will virtually beyond all doubt observe this, and then choose not to fetter us, or wipe us out. Thus it's a kind of pomposity, grandiosity, and pretension to fancy that we humans face such histrionic threats, and are worthy of such attention, excoriation, and annihilation from these ultra-superior beings, who clearly have better things to do with their time.
The fact is, folks, notwithstanding all the entertaining fiction and imaginative, creative scenarios, all our colorful and charming Martian friends are not coming to take away our women -- or worse.